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Study Information
Study Attribute Value
CEBS Accession Number: 002-01888-0001-0000-8
Chemical Name: trans-Cinnamaldehyde
CASRN: 14371-10-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 290481_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Negative 
No Activation  3  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/21/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 398 0.380 7.96 25.5 0.000
Test Chemical trans-Cinnamaldehyde 
 0.34      
 50 1051 530 0.504 10.60 25.5 32.659 
1.02      
 50 1050 697 0.664 13.94 25.5 74.625 
3.4       
 0 0 0 0.000 0.00 25.5 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1048 1261 1.203 25.22 25.5 216.532
Trend: 9.031        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 10/01/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 388 0.370 7.76 25.5 0.000
Test Chemical trans-Cinnamaldehyde 
2.04      
 50 1050 450 0.429 9.00 25.5 15.758 
2.55      
 50 1044 420 0.402 8.40 25.5 8.662 
3.06      
 50 1047 452 0.432 9.04 25.5 16.606
Positive Control Mitomycin-C 
 0.01      
 50 1050 1682 1.602 33.64 25.5 332.679
Trend: 1.759        
Probability: 0.039        

Trial #: 3    Activation: No Activation    Date: 10/21/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 484 0.465 9.68 25.5 0.000
Test Chemical trans-Cinnamaldehyde 
3.4       
 50 1036 528 0.510 10.56 25.5 9.617 
5.1       
 50 1025 515 0.502 10.30 25.5 8.066 
6.8       
 50 1039 657 0.632 13.14 25.5 36.005 
11.91      
 0 0 0 0.000 0.00 31.3 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1046 1597 1.527 31.94 25.5 228.381
Trend: 4.705        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/21/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1015 419 0.413 8.38 25.5 0.000
Test Chemical trans-Cinnamaldehyde 
3.4       
 50 1029 427 0.415 8.54 25.5 0.523 
10.2       
 50 1033 428 0.414 8.56 25.5 0.368 
34         
 50 1025 565 0.551 11.30 25.5 33.529
Positive Control Cyclophosphamide 
1.5       
 50 1032 1514 1.467 30.28 25.5 255.384
Trend: 4.482        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 10/01/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1028 443 0.431 8.86 25.5 0.000
Test Chemical trans-Cinnamaldehyde 
71.4       
 50 1027 447 0.435 8.94 25.5 1.001 
81.6       
 50 1028 551 0.536 11.02 25.5 24.379 
91.8       
 50 1033 624 0.604 12.48 28.8 40.176
Positive Control Cyclophosphamide 
1.5       
 50 1044 1753 1.679 35.06 25.5 289.647
Trend: 6.287        
Probability: 0.000