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Study Information
Study Attribute Value
CEBS Accession Number: 002-01889-0001-0000-9
Chemical Name: Cinnamyl anthranilate
CASRN: 87-29-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 023229_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/03/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1037 416 0.401 8.32 26.0 -2.643
Dimethyl Sulfoxide 
0         
 50 1046 431 0.412 8.62 26.0 0.000
Test Chemical Cinnamyl anthranilate 
 0.05      
 50 1046 377 0.360 7.54 26.0 -12.529 
 0.16      
 50 1043 393 0.377 7.86 26.0 -8.554 
 0.5       
 50 1044 354 0.339 7.08 26.0 -17.708 
1.6       
 50 1045 425 0.407 8.50 26.0 -1.298 
5         
 50 1046 418 0.400 8.36 26.0 -3.016 
16         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.005     
 50 1050 1387 1.321 27.74 26.0 220.584
Mitomycin-C 
 0.01      
 50 1046 2129 2.035 42.58 26.0 393.968
Trend: 0.245        
Probability: 0.403        

Trial #: 2    Activation: No Activation    Date: 06/29/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 414 0.398 8.28 26.0 7.460
Dimethyl Sulfoxide 
0         
 50 1042 386 0.370 7.72 26.0 0.000
Test Chemical Cinnamyl anthranilate 
2         
 50 1034 415 0.401 8.30 26.0 8.345 
5         
 50 1039 387 0.372 7.74 26.0 0.549 
7.5       
 50 1043 400 0.384 8.00 26.0 3.528 
10         
 50 1038 420 0.405 8.40 26.0 9.228 
15         
 50 1045 390 0.373 7.80 26.0 0.746
Positive Control Mitomycin-C 
 0.01      
 50 1042 1978 1.898 39.56 26.0 412.435
Trend: 0.136        
Probability: 0.446        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/03/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 468 0.449 9.36 26.0 -1.793
Dimethyl Sulfoxide 
0         
 50 1044 477 0.457 9.54 26.0 0.000
Test Chemical Cinnamyl anthranilate 
 0.05      
 50 1046 501 0.479 10.02 26.0 4.831 
 0.16      
 50 1046 435 0.416 8.70 26.0 -8.979 
 0.5       
 50 1046 445 0.425 8.90 26.0 -6.887 
1.6       
 50 1042 476 0.457 9.52 26.0 -0.018 
5         
 50 1054 446 0.423 8.92 26.0 -7.386 
16         
 50 1047 487 0.465 9.74 26.0 1.804 
50         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1044 1703 1.631 34.06 26.0 257.023
Cyclophosphamide 
2         
 50 1047 2553 2.438 51.06 26.0 433.687
Trend: -0.423        
Probability: 0.664        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/29/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 511 0.491 10.22 26.0 0.000
Negative (Not Specified) 
0         
 50 1040 554 0.533 11.08 26.0 8.519
Test Chemical Cinnamyl anthranilate 
10         
 50 1034 461 0.446 9.22 26.0 -9.174 
20         
 50 1044 446 0.427 8.92 26.0 -12.971 
30         
 50 1044 461 0.442 9.22 26.0 -10.044 
40         
 0 0 0 0.000 0.00 0.0 N/A 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1046 3257 3.114 65.14 26.0 534.331
Trend: -1.785        
Probability: 0.963