Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01889-0010-0000-9
Chemical Name:	Cinnamyl anthranilate
CASRN:	87-29-6
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	218374
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call:
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	59	90	139	78	83
			62	103	149	80
			71	108	195	92
Test Chemical	Cinnamyl anthranilate	25	75	114	200	89	87
			78	114	200	85	87
		50	37	45	230	209	151*
			69	88	191	93	151*
		75	23	4	1141	1666	1490*
			34	8	1334	1314	1490*
		87.5

Positive Control	Hycanthone	10	32	30	712	738	723*
			28	22	584	708	723*
	Hycanthone	500	34	34	1019	999	1038*
			33	33	1071	1076	1038*

Induced S9 Trial: 1 Experiment Call:
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	91	121	288	105	112
			77	84	259	112
			77	95	273	118
Test Chemical	Cinnamyl anthranilate	12.5	65	59	432	223	219*
			73	60	470	215	219*
		25	58	23	609	348	327*
			64	25	591	306	327*
		37.5	30	4	425	478	517*
			25	2	415	557	517*
		50

Positive Control	3-Methylcholanthrene	6	24	8	600	828	742*
Positive Control			27	9	531	656	742*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination