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Study Information
Study Attribute Value
CEBS Accession Number: 002-01889-0010-0000-9
Chemical Name: Cinnamyl anthranilate
CASRN: 87-29-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 218374
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call:
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 59 90 139 78 83
    62 103 149 80
    71 108 195 92
Test Chemical Cinnamyl anthranilate 
25         
 75 114 200 89 87
    78 114 200 85
  
50         
 37 45 230 209 151*
    69 88 191 93
  
75         
 23 4 1141 1666 1490*
    34 8 1334 1314
  
87.5       
   
Positive Control Hycanthone 
10         
 32 30 712 738 723*
    28 22 584 708
Hycanthone 
500         
 34 34 1019 999 1038*
    33 33 1071 1076

Induced S9 Trial: 1 Experiment Call:
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 91 121 288 105 112
    77 84 259 112
    77 95 273 118
Test Chemical Cinnamyl anthranilate 
12.5       
 65 59 432 223 219*
    73 60 470 215
  
25         
 58 23 609 348 327*
    64 25 591 306
  
37.5       
 30 4 425 478 517*
    25 2 415 557
  
50         
   
Positive Control 3-Methylcholanthrene 
6         
 24 8 600 828 742*
    27 9 531 656

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination