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Study Information
Study Attribute Value
CEBS Accession Number: 002-01890-0002-0000-2
Chemical Name: Citral
CASRN: 5392-40-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 881385_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 07/13/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 2.0 0 0.000 0.0 4 0.040 2.0 0 0.000 0.0
Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Citral 
12.5       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
20.2       
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
25.3       
 100 9 0.090 6.0 0 0.000 0.0 8 0.080 6.0 1 0.010 1.0 
40.3       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 12 0.120 11.0 4 0.040 4.0 8 0.080 7.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 7 0.280 28.0 3 0.120 12.0 4 0.160 16.0 0 0.000 0.0
Trend: 1.965 0.000 1.965  
Probability: 0.025 0.000 0.025  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/27/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Citral 
30.3       
 100 6 0.060 6.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
40.3       
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
50.5       
 75 6 0.080 6.6 1 0.013 1.3 4 0.053 5.3 1 0.013 1.3 
60.6       
 100 5 0.050 5.0 4 0.040 4.0 1 0.010 1.0 0 0.000 0.0 
70.7       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
3.8       
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Cyclophosphamide 
62.5       
 25 18 0.720 52.0 11 0.440 36.0 7 0.280 20.0 0 0.000 0.0
Trend: 1.246 2.054 -0.089  
Probability: 0.106 0.020 0.536