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Study Information
Study Attribute Value
CEBS Accession Number: 002-01900-0001-0000-3
Chemical Name: Coconut oil acid diethanolamine condensate
CASRN: 68603-42-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 898613_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/22/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 397 0.379 7.94 26.0 0.000
Test Chemical Coconut oil acid diethanolamine condensate 
 0.5       
 50 1050 341 0.325 6.82 26.0 -14.269 
1.6       
 50 1050 392 0.373 7.84 26.0 -1.448 
5         
 50 1049 393 0.375 7.86 26.0 -1.102 
16         
 50 1048 375 0.358 7.50 26.0 -5.542
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 557 0.531 11.14 26.0 40.302
Mitomycin-C 
 0.005     
 10 210 231 1.100 23.10 26.0 190.378
Trend: 0.136        
Probability: 0.446        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/23/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1053 355 0.337 7.10 26.0 0.000
Test Chemical Coconut oil acid diethanolamine condensate 
 0.5       
 50 1048 407 0.388 8.14 26.0 15.195 
5         
 50 1049 435 0.415 8.70 26.0 23.002 
16         
 50 1045 408 0.390 8.16 26.0 15.809
Positive Control Cyclophosphamide 
 0.1       
 50 1049 522 0.498 10.44 26.0 47.603
Cyclophosphamide 
 0.6       
 10 210 269 1.281 26.90 26.0 279.956
Trend: 2.338        
Probability: 0.010        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/22/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 455 0.434 9.10 26.0 0.000
Test Chemical Coconut oil acid diethanolamine condensate 
5         
 50 1050 423 0.403 8.46 26.0 -7.210 
10         
 50 1049 473 0.451 9.46 26.0 3.857 
16         
 50 1049 373 0.356 7.46 26.0 -18.100 
30         
 50 1050 359 0.342 7.18 26.0 -21.249
Positive Control Cyclophosphamide 
 0.1       
 50 1050 569 0.542 11.38 26.0 24.817
Cyclophosphamide 
 0.6       
 10 209 212 1.014 21.20 26.0 133.636
Trend: -3.606        
Probability: 1.000