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Study Information
Study Attribute Value
CEBS Accession Number: 002-01900-0002-0000-4
Chemical Name: Coconut oil acid diethanolamine condensate
CASRN: 68603-42-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 898613_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/29/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: Coconut oil acid diethanolamine condensate
16         
200 3 0.015 1.5 2 0.010 1.0 1 0.005 0.5 0 0.000 0.0
30         
200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
50         
200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C
 0.0625    
200 35 0.175 16.5 11 0.055 5.5 24 0.120 11.5 0 0.000 0.0
Mitomycin-C
 0.25      
50 26 0.520 32.0 9 0.180 16.0 17 0.340 20.0 0 0.000 0.0
Trend: 1.107 -1.319 1.985  
Probability: 0.134 0.906 0.024  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/29/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Coconut oil acid diethanolamine condensate
16         
200 5 0.025 2.5 0 0.000 0.0 5 0.025 2.5 0 0.000 0.0
30         
200 4 0.020 2.0 3 0.015 1.5 1 0.005 0.5 0 0.000 0.0
50         
200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide
2.5       
200 39 0.195 17.5 10 0.050 5.0 29 0.145 13.5 0 0.000 0.0
Cyclophosphamide
7.5       
50 24 0.480 38.0 10 0.200 14.0 14 0.280 24.0 0 0.000 0.0
Trend: 0.582 1.858 -0.607  
Probability: 0.280 0.032 0.728