Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01900-0002-0000-4 |
Chemical Name: | Coconut oil acid diethanolamine condensate |
CASRN: | 68603-42-9 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 898613_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Coconut oil acid diethanolamine condensate | 16 | 200 | 3 | 0.015 | 1.5 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
30 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
50 | 200 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.0625 | 200 | 35 | 0.175 | 16.5 | 11 | 0.055 | 5.5 | 24 | 0.120 | 11.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 26 | 0.520 | 32.0 | 9 | 0.180 | 16.0 | 17 | 0.340 | 20.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.107 | -1.319 | 1.985 | ||||||||||||
Probability: | 0.134 | 0.906 | 0.024 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Coconut oil acid diethanolamine condensate | 16 | 200 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
30 | 200 | 4 | 0.020 | 2.0 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
50 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 2.5 | 200 | 39 | 0.195 | 17.5 | 10 | 0.050 | 5.0 | 29 | 0.145 | 13.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 7.5 | 50 | 24 | 0.480 | 38.0 | 10 | 0.200 | 14.0 | 14 | 0.280 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.582 | 1.858 | -0.607 | ||||||||||||
Probability: | 0.280 | 0.032 | 0.728 |