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Study Information
Study Attribute Value
CEBS Accession Number: 002-01902-0002-0000-6
Chemical Name: Colchicine
CASRN: 64-86-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 103168_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/19/1982    Harvest Time: 14 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Colchicine 
160         
 100 10 0.100 9.0 2 0.020 2.0 8 0.080 7.0 0 0.000 0.0 
500         
 100 12 0.120 6.0 6 0.060 3.0 6 0.060 4.0 0 0.000 0.0 
1600         
 100 25 0.250 17.0 5 0.050 4.0 19 0.190 12.0 1 0.010 1.0 
5000         
 100 40 0.400 26.0 3 0.030 3.0 32 0.320 21.0 5 0.050 5.0
Positive Control: Mitomycin-C 
 0.15      
 100 42 0.420 31.0 17 0.170 16.0 24 0.240 21.0 1 0.010 1.0
Trend: 4.993 1.653 4.189  
Probability: 0.000 0.049 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/19/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 10 0.100 8.0 2 0.020 2.0 8 0.080 7.0 0 0.000 0.0
Test Chemical: Colchicine 
500         
 100 13 0.130 12.0 3 0.030 3.0 10 0.100 9.0 0 0.000 0.0 
1600         
 100 11 0.110 8.0 2 0.020 2.0 9 0.090 7.0 0 0.000 0.0 
5000         
 100 14 0.140 11.0 3 0.030 3.0 11 0.110 9.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 25 0.250 21.0 7 0.070 6.0 18 0.180 16.0 0 0.000 0.0
Trend: 0.374 0.285 0.328  
Probability: 0.354 0.388 0.372  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/22/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Colchicine 
3000         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0 
4000         
 100 9 0.090 7.0 1 0.010 1.0 8 0.080 6.0 0 0.000 0.0 
5000         
 100 8 0.080 7.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 18 0.180 14.0 8 0.080 8.0 10 0.100 8.0 0 0.000 0.0
Trend: 1.329 1.146 1.111  
Probability: 0.092 0.126 0.133