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Study Information
Study Attribute Value
CEBS Accession Number: 002-01906-0001-0000-9
Chemical Name: Coumaphos
CASRN: 56-72-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 051728_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/08/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 345 0.330 6.90 27.0 0.000
Test Chemical Coumaphos 
100         
 50 1047 384 0.367 7.68 27.0 11.092 
300         
 50 1052 390 0.371 7.80 27.0 12.291 
1000         
 50 1045 340 0.325 6.80 27.0 -1.449
Positive Control Mitomycin-C 
 0.0015    
 50 1044 556 0.533 11.12 27.0 61.314
Mitomycin-C 
 0.01      
 10 211 292 1.384 29.20 27.0 319.177
Trend: -0.152        
Probability: 0.560        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/08/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Acetone 
0         
 50 1050 366 0.349 7.32 26.0 0.000
Test Chemical Coumaphos 
100         
 50 1046 366 0.350 7.32 26.0 0.382 
300         
 50 1049 404 0.385 8.08 26.0 10.488 
1000         
 50 1048 385 0.367 7.70 26.0 5.392
Positive Control Cyclophosphamide 
 0.5       
 50 1043 577 0.553 11.54 26.0 58.708
Cyclophosphamide 
2.5       
 10 209 241 1.153 24.10 26.0 230.810
Trend: 1.082        
Probability: 0.140