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Study Information
Study Attribute Value
CEBS Accession Number: 002-01907-0002-0000-1
Chemical Name: Coumarin
CASRN: 91-64-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 020274_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Coumarin 
50         
 100 8 0.080 8.0 0 0.000 0.0 8 0.080 8.0 0 0.000 0.0 
160         
 100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0 
500         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 41 0.410 27.0 12 0.120 12.0 29 0.290 20.0 0 0.000 0.0
Trend: 0.645 1.897 0.096  
Probability: 0.259 0.029 0.462  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Test Chemical: Coumarin 
160         
 100 11 0.110 10.0 4 0.040 4.0 7 0.070 7.0 0 0.000 0.0 
500         
 100 14 0.140 12.0 4 0.040 4.0 10 0.100 8.0 0 0.000 0.0 
1600         
 100 51 0.510 37.0 5 0.050 4.0 46 0.460 33.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 30 0.300 26.0 7 0.070 7.0 23 0.230 22.0 0 0.000 0.0
Trend: 5.989 1.572 5.619  
Probability: 0.000 0.058 0.000