COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01907-0002-0000-1
Chemical Name: Coumarin
CASRN: 91-64-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 020274_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Coumarin
50         
100 8 0.080 8.0 0 0.000 0.0 8 0.080 8.0 0 0.000 0.0
160         
100 6 0.060 6.0 0 0.000 0.0 6 0.060 6.0 0 0.000 0.0
500         
100 8 0.080 7.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.15      
100 41 0.410 27.0 12 0.120 12.0 29 0.290 20.0 0 0.000 0.0
Trend: 0.645 1.897 0.096  
Probability: 0.259 0.029 0.462  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/26/1982    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0
Test Chemical: Coumarin
160         
100 11 0.110 10.0 4 0.040 4.0 7 0.070 7.0 0 0.000 0.0
500         
100 14 0.140 12.0 4 0.040 4.0 10 0.100 8.0 0 0.000 0.0
1600         
100 51 0.510 37.0 5 0.050 4.0 46 0.460 33.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 30 0.300 26.0 7 0.070 7.0 23 0.230 22.0 0 0.000 0.0
Trend: 5.989 1.572 5.619  
Probability: 0.000 0.058 0.000