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Study Information
Study Attribute Value
CEBS Accession Number: 002-01912-0001-0000-6
Chemical Name: Crotonaldehyde
CASRN: 4170-30-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 497791_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/29/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 480 0.459 9.60 26.0 0.000
Test Chemical Crotonaldehyde 
 0.16      
 50 1043 448 0.430 8.96 26.0 -6.488 
 0.5       
 50 1045 578 0.553 11.56 26.0 20.417 
1.6       
 50 1045 747 0.715 14.94 26.0 55.625
Positive Control Triethylenemelamine 
 0.015     
 50 1045 1596 1.527 31.92 26.0 232.500
Trend: 8.766        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/29/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 420 0.403 8.40 26.0 0.000
Test Chemical Crotonaldehyde 
1.6       
 50 1035 532 0.514 10.64 26.0 27.523 
5         
 50 1034 524 0.507 10.48 26.0 25.727 
16         
 50 1030 934 0.907 18.68 28.0 124.972
Positive Control Cyclophosphamide 
1         
 50 1036 1711 1.652 34.22 26.0 309.740
Trend: 14.196        
Probability: 0.000