Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01912-0002-0000-7 |
Chemical Name: | Crotonaldehyde |
CASRN: | 4170-30-3 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 497791_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Crotonaldehyde | 0.5 | 100 | 5 | 0.050 | 4.0 | 1 | 0.010 | 1.0 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 |
1.6 | 100 | 14 | 0.140 | 10.0 | 7 | 0.070 | 6.0 | 7 | 0.070 | 5.0 | 0 | 0.000 | 0.0 | ||
5 | 100 | 64 | 0.640 | 38.0 | 39 | 0.390 | 34.0 | 25 | 0.250 | 17.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Triethylenemelamine | 0.015 | 100 | 31 | 0.310 | 25.0 | 18 | 0.180 | 18.0 | 13 | 0.130 | 11.0 | 0 | 0.000 | 0.0 |
Trend: | 7.704 | 7.874 | 4.528 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Crotonaldehyde | 1.6 | 100 | 3 | 0.030 | 3.0 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
5 | 100 | 7 | 0.070 | 7.0 | 5 | 0.050 | 5.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
16 | 100 | 41 | 0.410 | 30.0 | 31 | 0.310 | 25.0 | 10 | 0.100 | 10.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 54 | 0.540 | 35.0 | 38 | 0.380 | 31.0 | 16 | 0.160 | 11.0 | 0 | 0.000 | 0.0 |
Trend: | 6.721 | 6.107 | 3.916 | ||||||||||||
Probability: | 0.000 | 0.000 | 0.000 |