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Study Information
Study Attribute Value
CEBS Accession Number: 002-01916-0001-0000-0
Chemical Name: Cupferron
CASRN: 135-20-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 705717_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/04/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 451 0.430 9.02 26.0 0.000
Negative (Not Specified) 
0         
 50 1046 409 0.391 8.18 26.0 -9.139
Test Chemical Cupferron 
2.5       
 50 1044 436 0.418 8.72 26.0 -2.956 
8.3       
 50 1047 455 0.435 9.10 26.0 0.983 
25         
 50 1045 472 0.452 9.44 26.0 4.957 
83         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 686 0.653 13.72 26.0 51.817
Mitomycin-C 
 0.005     
 10 210 280 1.333 28.00 26.0 209.830
Trend: 0.883        
Probability: 0.189        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/04/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1051 488 0.464 9.76 26.0 2.150
Dimethyl Sulfoxide 
0         
 50 1056 480 0.455 9.60 31.0 0.000
Test Chemical Cupferron 
250         
 50 1047 467 0.446 9.34 26.0 -1.872 
833         
 50 1041 650 0.624 13.00 26.0 37.368 
2500         
 50 1045 1016 0.972 20.32 31.0 113.895
Positive Control Cyclophosphamide 
 0.125     
 50 1050 658 0.627 13.16 26.0 37.867
Cyclophosphamide 
 0.5       
 10 209 257 1.230 25.70 26.0 170.526
Trend: 15.789        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/27/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 490 0.467 9.80 26.0 1.986
Dimethyl Sulfoxide 
0         
 50 1049 480 0.458 9.60 31.0 0.000
Test Chemical Cupferron 
1500         
 25 524 489 0.933 19.56 31.0 103.944 
2000         
 25 526 596 1.133 23.84 31.0 147.625 
2500         
 25 524 675 1.288 27.00 31.0 181.518
Positive Control Cyclophosphamide 
 0.125     
 50 1045 671 0.642 13.42 26.0 40.327
Cyclophosphamide 
 0.5       
 10 208 247 1.188 24.70 26.0 159.518
Trend: 18.487        
Probability: 0.000