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Study Information
Study Attribute Value
CEBS Accession Number: 002-01916-0002-0000-1
Chemical Name: Cupferron
CASRN: 135-20-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 705717_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 07/27/1989    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cupferron 
12         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
25         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
54         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 7 0.280 24.0 2 0.080 8.0 5 0.200 16.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/15/1989    Harvest Time: 13.4 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cupferron 
2000         
 100 38 0.380 23.0 10 0.100 10.0 17 0.170 17.0 11 0.110 2.0 
2250         
 50 19 0.380 32.0 7 0.140 14.0 11 0.220 18.0 1 0.020 2.0 
2500         
 100 31 0.310 22.0 10 0.100 7.0 20 0.200 15.0 1 0.010 1.0
Positive Control: Cyclophosphamide 
20         
 25 23 0.920 44.0 6 0.240 24.0 7 0.280 20.0 10 0.400 4.0
Trend: 6.159 3.244 4.730  
Probability: 0.000 0.001 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/27/1989    Harvest Time: 13.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cupferron 
541         
 200 7 0.035 3.5 1 0.005 0.5 1 0.005 0.5 5 0.025 2.5 
1163         
 200 18 0.090 7.5 5 0.025 2.0 12 0.060 6.0 1 0.005 0.5 
2500         
 100 34 0.340 21.0 4 0.040 4.0 12 0.120 9.0 18 0.180 9.0
Positive Control: Cyclophosphamide 
20         
 25 6 0.240 24.0 6 0.240 24.0 0 0.000 0.0 0 0.000 0.0
Trend: 6.832 3.071 4.987  
Probability: 0.000 0.001 0.000