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Study Information
Study Attribute Value
CEBS Accession Number: 002-01918-0001-0000-2
Chemical Name: Turmeric, oleoresin (curcumin)
CASRN: 8024-37-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 001566_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/05/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 383 0.366 7.66 26.0 0.000
Test Chemical Turmeric, oleoresin (curcumin) 
 0.16      
 50 1048 415 0.396 8.30 26.0 8.252 
 0.5       
 50 1042 417 0.400 8.34 26.0 9.400 
1.6       
 50 1048 437 0.417 8.74 26.0 13.990 
5         
 50 1049 488 0.465 9.76 26.0 27.172
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 509 0.485 10.18 26.0 32.518
Mitomycin-C 
 0.005     
 10 210 289 1.376 28.90 26.0 276.207
Trend: 3.519        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/08/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 460 0.438 9.20 26.0 0.000
Test Chemical Turmeric, oleoresin (curcumin) 
 0.16      
 50 1050 448 0.427 8.96 26.0 -2.516 
 0.5       
 50 1049 435 0.415 8.70 26.0 -5.254 
1.6       
 50 1045 456 0.436 9.12 26.0 -0.300 
5         
 50 1046 542 0.518 10.84 26.0 18.389
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 559 0.533 11.18 26.0 21.753
Mitomycin-C 
 0.005     
 10 210 261 1.243 26.10 26.0 183.966
Trend: 2.612        
Probability: 0.005        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/18/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 434 0.414 8.68 26.0 0.000
Test Chemical Turmeric, oleoresin (curcumin) 
 0.16      
 50 1049 522 0.498 10.44 26.0 20.276 
 0.5       
 50 1050 457 0.435 9.14 26.0 5.199 
1.6       
 50 1050 497 0.473 9.94 26.0 14.407 
5         
 50 1050 493 0.470 9.86 26.0 13.486
Positive Control Cyclophosphamide 
 0.1       
 50 1049 595 0.567 11.90 26.0 37.097
Cyclophosphamide 
 0.6       
 10 209 251 1.201 25.10 26.0 190.277
Trend: 1.325        
Probability: 0.093        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/08/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 391 0.372 7.82 26.0 0.000
Test Chemical Turmeric, oleoresin (curcumin) 
 0.16      
 50 1050 460 0.438 9.20 26.0 17.647 
 0.5       
 50 1051 427 0.406 8.54 26.0 9.103 
1.6       
 50 1049 484 0.461 9.68 26.0 23.903 
5         
 50 1048 482 0.460 9.64 26.0 23.509
Positive Control Cyclophosphamide 
 0.1       
 50 1049 530 0.505 10.60 26.0 35.679
Cyclophosphamide 
 0.6       
 10 211 237 1.123 23.70 26.0 201.633
Trend: 3.111        
Probability: 0.001