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Study Information
Study Attribute Value
CEBS Accession Number: 002-01918-0002-0000-3
Chemical Name: Turmeric, oleoresin (curcumin)
CASRN: 8024-37-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 001566_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 10/02/1986    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Turmeric, oleoresin (curcumin) 
5         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
10         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
16         
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 50 0.250 20.5 29 0.145 13.0 21 0.105 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 32.0 11 0.220 18.0 9 0.180 16.0 0 0.000 0.0
Trend: 2.487 1.800 1.893  
Probability: 0.006 0.036 0.029  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/02/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Test Chemical: Turmeric, oleoresin (curcumin) 
3         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0 
5         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
10         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 36 0.180 16.0 10 0.050 4.5 26 0.130 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 25 0.500 42.0 7 0.140 12.0 18 0.360 32.0 0 0.000 0.0
Trend: 0.263 -1.327 0.263  
Probability: 0.396 0.908 0.396  


Trial #:2   Activation: No Activation    Date: 02/04/1988    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Turmeric, oleoresin (curcumin) 
5         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
10         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
16         
 200 8 0.040 4.0 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 30 0.150 15.0 9 0.045 4.5 21 0.105 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 19 0.380 36.0 8 0.160 16.0 11 0.220 22.0 0 0.000 0.0
Trend: 2.574 0.560 2.546  
Probability: 0.005 0.288 0.005