COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01918-0002-0000-3
Chemical Name: Turmeric, oleoresin (curcumin)
CASRN: 8024-37-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 001566_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 10/02/1986    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Turmeric, oleoresin (curcumin) 
5         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
10         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
16         
 200 7 0.035 3.5 2 0.010 1.0 5 0.025 2.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 50 0.250 20.5 29 0.145 13.0 21 0.105 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 32.0 11 0.220 18.0 9 0.180 16.0 0 0.000 0.0
Trend: 2.487 1.800 1.893  
Probability: 0.006 0.036 0.029  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/02/1986    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0
Test Chemical: Turmeric, oleoresin (curcumin) 
3         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0 
5         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
10         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 36 0.180 16.0 10 0.050 4.5 26 0.130 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 25 0.500 42.0 7 0.140 12.0 18 0.360 32.0 0 0.000 0.0
Trend: 0.263 -1.327 0.263  
Probability: 0.396 0.908 0.396  


Trial #:2   Activation: No Activation    Date: 02/04/1988    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Turmeric, oleoresin (curcumin) 
5         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
10         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
16         
 200 8 0.040 4.0 1 0.005 0.5 7 0.035 3.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 30 0.150 15.0 9 0.045 4.5 21 0.105 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 19 0.380 36.0 8 0.160 16.0 11 0.220 22.0 0 0.000 0.0
Trend: 2.574 0.560 2.546  
Probability: 0.005 0.288 0.005