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Study Information
Study Attribute Value
CEBS Accession Number: 002-01924-0001-0000-9
Chemical Name: Cyclohexanone oxime
CASRN: 100-64-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: A35717_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Questionable 

Trial #:1   Activation: No Activation    Date: 06/17/1992    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 0.5 0 0.000 0.0 4 0.020 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 0.5 0 0.000 0.0 2 0.010 0.5 0 0.000 0.0
Test Chemical: Cyclohexanone oxime 
500         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
1000         
 200 7 0.035 3.5 1 0.005 0.5 6 0.030 3.0 0 0.000 0.0 
2000         
 200 3 0.015 0.5 0 0.000 0.0 3 0.015 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 16 0.640 32.0 3 0.120 12.0 13 0.520 28.0 0 0.000 0.0
Trend: 0.520 0.000 0.569  
Probability: 0.301 0.500 0.285  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/27/1992    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cyclohexanone oxime 
1081         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
2325         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
5000         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
20         
 25 14 0.560 44.0 7 0.280 28.0 7 0.280 24.0 0 0.000 0.0
Trend: 1.003 -1.267 2.328  
Probability: 0.158 0.897 0.010  


Trial #:2   Activation: No Activation    Date: 02/27/1992    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Negative (Not Specified) 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cyclohexanone oxime 
1081         
 200 10 0.050 4.5 0 0.000 0.0 10 0.050 4.5 0 0.000 0.0 
2325         
 200 4 0.020 1.5 2 0.010 0.5 1 0.005 0.5 1 0.005 0.5 
5000         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.4       
 25 10 0.400 36.0 5 0.200 20.0 5 0.200 20.0 0 0.000 0.0
Trend: -1.049 -0.633 -1.041  
Probability: 0.853 0.737 0.851