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Study Information
Study Attribute Value
CEBS Accession Number: 002-01933-0001-0000-9
Chemical Name: Cytarabine hydrochloride
CASRN: 69-74-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 070484_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/16/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 368 0.350 7.36 26.0 0.000
Water 
0         
 50 1050 352 0.335 7.04 31.0 -4.348
Test Chemical Cytarabine hydrochloride 
 0.05      
 50 1050 448 0.427 8.96 26.0 21.739 
 0.17      
 50 1047 520 0.497 10.40 26.0 41.709 
 0.5       
 50 1049 652 0.622 13.04 31.0 77.343 
1.7       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 513 0.489 10.26 26.0 39.402
Mitomycin-C 
 0.004     
 10 210 200 0.952 20.00 26.0 171.739
Trend: 9.260        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/25/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 379 0.361 7.58 31.0 7.772
Water 
0         
 50 1048 351 0.335 7.02 26.0 0.000
Test Chemical Cytarabine hydrochloride 
 0.16      
 50 1050 451 0.430 9.02 26.0 28.245 
 0.31      
 50 1050 552 0.526 11.04 26.0 56.965 
 0.63      
 50 1050 655 0.624 13.10 31.0 86.254 
1.25      
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 486 0.463 9.72 26.0 38.198
Mitomycin-C 
 0.004     
 10 210 195 0.929 19.50 26.0 177.249
Trend: 10.080        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/20/1991    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1050 402 0.383 8.04 31.0 5.588
Water 
0         
 50 1048 380 0.363 7.60 26.0 0.000
Test Chemical Cytarabine hydrochloride 
50         
 50 1049 435 0.415 8.70 26.0 14.365 
167         
 50 1048 531 0.507 10.62 26.0 39.737 
500         
 50 1044 600 0.575 12.00 31.0 58.500 
1667         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1049 554 0.528 11.08 26.0 45.650
Cyclophosphamide 
 0.5       
 10 210 182 0.867 18.20 26.0 139.018
Trend: 7.731        
Probability: 0.000