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Study Information
Study Attribute Value
CEBS Accession Number: 002-01933-0002-0000-0
Chemical Name: Cytarabine hydrochloride
CASRN: 69-74-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 070484_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 07/11/1991    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Cytarabine hydrochloride 
109         
 50 144 2.880 80.0 66 1.320 64.0 38 0.760 36.0 40 0.800 8.0 
234         
 50 134 2.680 76.0 44 0.880 50.0 50 1.000 52.0 40 0.800 8.0 
503         
 50 171 3.420 90.0 50 1.000 60.0 61 1.220 52.0 60 1.200 12.0
Positive Control: Mitomycin-C 
 0.4       
 25 43 1.720 68.0 18 0.720 56.0 15 0.600 40.0 10 0.400 4.0
Trend: 14.489 10.712 10.454  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/11/1991    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Cytarabine hydrochloride 
503         
 50 43 0.860 34.0 26 0.520 28.0 7 0.140 12.0 10 0.200 2.0 
1081         
 50 62 1.240 44.0 31 0.620 34.0 11 0.220 16.0 20 0.400 4.0 
2325         
 50 192 3.840 86.0 39 0.780 50.0 33 0.660 40.0 120 2.400 24.0
Positive Control: Cyclophosphamide 
20         
 25 52 2.080 64.0 15 0.600 40.0 7 0.280 20.0 30 1.200 12.0
Trend: 13.279 9.721 8.237  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 07/23/1991    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Water 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: Cytarabine hydrochloride 
109         
 50 174 3.480 90.0 80 1.600 68.0 34 0.680 48.0 60 1.200 12.0 
234         
 50 146 2.920 76.0 75 1.500 58.0 29 0.580 38.0 42 0.840 12.0 
503         
 50 149 2.980 88.0 48 0.960 58.0 40 0.800 50.0 61 1.220 14.0
Positive Control: Mitomycin-C 
 0.4       
 25 73 2.920 80.0 26 1.040 56.0 7 0.280 24.0 40 1.600 16.0
Trend: 14.137 10.810 9.300  
Probability: 0.000 0.000 0.000