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Study Information
Study Attribute Value
CEBS Accession Number: 002-01934-0002-0000-1
Chemical Name: Cytembena
CASRN: 21739-91-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 404197_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/26/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 1.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Cytembena 
24.9       
 100 9 0.090 7.0 0 0.000 0.0 7 0.070 5.0 2 0.020 1.0 
40         
 25 16 0.640 36.0 5 0.200 16.0 11 0.440 24.0 0 0.000 0.0 
50         
 25 55 2.200 68.0 16 0.640 48.0 29 1.160 52.0 10 0.400 4.0
Positive Control: Mitomycin-C 
 0.05      
 100 31 0.310 26.0 14 0.140 14.0 17 0.170 15.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 18 0.720 36.0 7 0.280 20.0 11 0.440 28.0 0 0.000 0.0
Trend: 8.284 7.949 6.767  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/28/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 6 0.030 3.0 1 0.005 1.0 5 0.025 3.0 0 0.000 0.0
Negative (Not Specified) 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: Cytembena 
74.3       
 25 41 1.640 44.0 21 0.840 36.0 10 0.400 24.0 10 0.400 4.0 
100         
 10 38 3.800 80.0 15 1.500 70.0 13 1.300 50.0 10 1.000 10.0 
247.5       
 10 63 6.300 80.0 8 0.800 20.0 5 0.500 30.0 50 5.000 50.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
6.25      
 200 28 0.140 12.0 8 0.040 4.0 20 0.100 10.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 25 1.000 60.0 11 0.440 36.0 14 0.560 40.0 0 0.000 0.0
Trend: 10.186 6.744 5.690  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 08/28/1985    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 3.0 1 0.005 1.0 4 0.020 2.0 1 0.005 1.0
Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Cytembena 
7.6       
 200 9 0.045 5.0 3 0.015 2.0 6 0.030 3.0 0 0.000 0.0 
10         
 200 10 0.050 4.0 0 0.000 0.0 9 0.045 4.0 1 0.005 1.0 
25.3       
 25 41 1.640 56.0 8 0.320 24.0 32 1.280 48.0 1 0.040 4.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.05      
 200 60 0.300 19.0 24 0.120 9.0 36 0.180 14.0 0 0.000 0.0
Mitomycin-C 
 0.08      
 25 10 0.400 32.0 7 0.280 28.0 3 0.120 8.0 0 0.000 0.0
Trend: 7.806 4.351 7.362  
Probability: 0.000 0.000 0.000