Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01934-0010-0000-0
Chemical Name:	Cytembena
CASRN:	21739-91-3
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	644192
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	88	105	102	39	47
			100	92	131	44
			107	103	154	48
			104	100	184	59
Test Chemical	Cytembena	6.25	110	104	125	38	41
			108	92	141	43	41
		12.5	139r	104	164	39
			104	91	133	42
		25	92	74	148	54	51
			91	85	133	49	51
		50	89	59	307	115	109*
			93	51	288	103	109*
		100	25	2	335	441	452*
			26	4	368	463	452*
Positive Control	Methyl Methane Sulfonate	15	68	40	408	200	202*
			56	37	343	203	202*
	Methyl Methane Sulfonate	250	78	59	525	225	199*
			79	71	407	173	199*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	65	91	93	48	50
			83	101	113	45
			81	104	128	53
			80	104	133	55
Test Chemical	Cytembena	25	67	59	227	114	134*
			63	57	291	154	134*
		50	43	16	617	478	464*
			49	17	656	449	464*
		75	19	2	349	618	603*
			21	3	368	589	603*
		100

Positive Control	Methyl Methane Sulfonate	15	34	25	256	255	233*
			35	25	223	211	233*
	Methyl Methane Sulfonate	250	60	77	365	204	224*
			63	72	461	243	224*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination