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Study Information
Study Attribute Value
CEBS Accession Number: 002-01934-0012-0000-2
Chemical Name: Cytembena
CASRN: 21739-91-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 483291_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/13/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9418
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 12.50 ± 2.03 0.0000
Test Chemical Cytembena 
50         
 8 2.75 ± 0.75 0.4125
  
100         
 7 1.43 ± 0.72 0.8521
  
200         
 8 1.25 ± 0.53 0.9038
Vehicle Control No Stressor 
 0         
 8 2.50 ± 1.12 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/24/91 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0118
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 7 19.71 ± 2.16 0.0000
Test Chemical Cytembena 
25         
 8 2.75 ± 0.92 0.0584
  
50         
 8 2.25 ± 1.28 0.1232
  
100         
 8 4.00 ± 1.85 0.0077
Vehicle Control No Stressor 
 0         
 7 1.14 ± 0.40 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed