| Study Attribute | Value | 
|---|---|
| CEBS Accession Number: | 002-01934-0012-0000-2 | 
| Chemical Name: | Cytembena | 
| CASRN: | 21739-91-3 | 
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics | 
| NTP Study ID: | 483291_CA | 
| Study Result: | Negative | 
| Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P | 
|---|---|---|---|---|---|---|---|
| CA | 03/13/89 | 17 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 17 hour | 0.9418 | 
| Test Group | Dose (mg/kg) | n | Percent Cells w/ Aberrations (Mean ± SEM) | Pairwise P | |
|---|---|---|---|---|---|
| Positive Control | Mitomycin-C | 1 | 8 | 12.50 ± 2.03 | 0.0000 | 
| Test Chemical | Cytembena | 50 | 8 | 2.75 ± 0.75 | 0.4125 | 
| 100 | 7 | 1.43 ± 0.72 | 0.8521 | ||
| 200 | 8 | 1.25 ± 0.53 | 0.9038 | ||
| Vehicle Control | No Stressor | 0 | 8 | 2.50 ± 1.12 | 0.0000 | 
| Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P | 
|---|---|---|---|---|---|---|---|
| CA | 09/24/91 | 36 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 36 hour | 0.0118 | 
| Test Group | Dose (mg/kg) | n | Percent Cells w/ Aberrations (Mean ± SEM) | Pairwise P | |
|---|---|---|---|---|---|
| Positive Control | Mitomycin-C | 1 | 7 | 19.71 ± 2.16 | 0.0000 | 
| Test Chemical | Cytembena | 25 | 8 | 2.75 ± 0.92 | 0.0584 | 
| 50 | 8 | 2.25 ± 1.28 | 0.1232 | ||
| 100 | 8 | 4.00 ± 1.85 | 0.0077 | ||
| Vehicle Control | No Stressor | 0 | 7 | 1.14 ± 0.40 | 0.0000 | 
INHAL: Inhalation
n: Number of animals analyzed
 
                        