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Study Information
Study Attribute Value
CEBS Accession Number: 002-01936-0002-0000-3
Chemical Name: D & C green no. 5
CASRN: 4403-90-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 764297_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/16/1987    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: D & C green no. 5 
160         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
500         
 200 3 0.015 1.5 0 0.000 0.0 3 0.015 1.5 0 0.000 0.0 
1000         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 39 0.195 18.0 12 0.060 6.0 27 0.135 13.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 18 0.360 32.0 8 0.160 16.0 10 0.200 20.0 0 0.000 0.0
Trend: 0.412 0.000 0.412  
Probability: 0.340 0.000 0.340  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/16/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0
Test Chemical: D & C green no. 5 
160         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
500         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
1000         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 48 0.240 19.5 9 0.045 4.5 39 0.195 16.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 20 0.400 34.0 6 0.120 12.0 14 0.280 28.0 0 0.000 0.0
Trend: -0.333 -1.358 0.000  
Probability: 0.630 0.913 0.500