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Study Information
Study Attribute Value
CEBS Accession Number: 002-01940-0001-0000-7
Chemical Name: D & C red no. 9
CASRN: 5160-02-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 794744_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 10/03/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 419 0.412 8.38 25.5 0.000
Test Chemical D & C red no. 9 
5         
 50 1010 399 0.395 7.98 25.5 -4.019 
16.7       
 50 1002 417 0.416 8.34 25.5 1.112 
50         
 50 1016 399 0.393 7.98 25.5 -4.586 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1015 500 0.493 10.00 25.5 19.684
Mitomycin-C 
 0.01      
 5 99 102 1.030 20.40 25.5 150.322
Trend: -0.387        
Probability: 0.651        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/03/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1015 464 0.457 9.28 25.5 0.000
Test Chemical D & C red no. 9 
50         
 50 1009 367 0.364 7.34 25.5 -20.435 
166.7       
 50 992 386 0.389 7.72 25.5 -14.882 
500         
 50 1008 455 0.451 9.10 25.5 -1.259
Positive Control Cyclophosphamide 
 0.4       
 50 1019 612 0.601 12.24 25.5 31.379
Cyclophosphamide 
2         
 5 100 147 1.470 29.40 25.5 221.563
Trend: 0.058        
Probability: 0.477