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Study Information
Study Attribute Value
CEBS Accession Number: 002-01940-0002-0000-8
Chemical Name: D & C red no. 9
CASRN: 5160-02-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 794744_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 10/24/1985    Harvest Time: 10 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 6 0.030 3.0 2 0.010 1.0 4 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: D & C red no. 9 
37.1       
 200 4 0.020 2.0 0 0.000 0.0 2 0.010 1.0 2 0.010 1.0 
50         
 200 5 0.025 3.0 1 0.005 1.0 4 0.020 2.0 0 0.000 0.0 
123.8       
 200 5 0.025 3.0 2 0.010 1.0 3 0.015 2.0 0 0.000 0.0 
250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 200 26 0.130 7.0 6 0.030 3.0 10 0.050 5.0 10 0.050 1.0
Mitomycin-C 
 0.75      
 25 11 0.440 36.0 3 0.120 12.0 8 0.320 24.0 0 0.000 0.0
Trend: 0.731 0.268 0.939  
Probability: 0.232 0.394 0.174  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/24/1985    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: D & C red no. 9 
50         
 200 2 0.010 1.0 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 
123.8       
 200 6 0.030 3.0 1 0.005 1.0 4 0.020 2.0 1 0.005 1.0 
250         
 200 5 0.025 2.0 0 0.000 0.0 5 0.025 2.0 0 0.000 0.0 
375         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 17 0.085 8.0 5 0.025 3.0 12 0.060 6.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 14 0.560 44.0 5 0.200 20.0 9 0.360 32.0 0 0.000 0.0
Trend: -0.709 -1.084 -0.131  
Probability: 0.761 0.861 0.552