Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01940-0010-0000-7
Chemical Name:	D & C red no. 9
CASRN:	5160-02-1
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	832755_SCE
Study Result:	Positive

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	05/10/88	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	4.99 ± 0.394
Test Chemical	D & C red no. 9	1250	4	4.58 ± 0.283
		2500	4	4.27 ± 0.176
		5000	4	4.51 ± 0.193
Positive Control	Dimethylbenzanthracene	2.5	4	7.03 ± 0.335

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	09/07/88	42	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 42 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	5.36 ± 0.148
Test Chemical	D & C red no. 9	1250	4	7.12 ± 0.986
		2500	4	7.23 ± 0.174
		5000	4	8.82 ± 0.339
Positive Control	Dimethylbenzanthracene	2.5	4	15.06 ± 1.834

Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	12/20/88	42	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 42 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Corn Oil	0	4	5.92 ± 0.203
Test Chemical	D & C red no. 9	5000	4	8.27 ± 0.178
Positive Control	Dimethylbenzanthracene	25	4	19.18 ± 0.690

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed