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Study Information
Study Attribute Value
CEBS Accession Number: 002-01942-0001-0000-9
Chemical Name: D & C yellow no. 11
CASRN: 8003-22-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 296632_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/09/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1017 482 0.474 9.64 26.0 0.000
Test Chemical D & C yellow no. 11 
 0.27      
 50 1029 579 0.563 11.58 26.0 18.724 
 0.8       
 50 1015 651 0.641 13.02 26.0 35.328 
2.7       
 50 1000 871 0.871 17.42 34.5 83.777 
8         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 623 0.608 12.46 26.0 28.370
Mitomycin-C 
 0.01      
 5 102 216 2.118 43.20 26.0 346.815
Trend: 11.363        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/24/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 507 0.492 10.14 26.0 0.000
Test Chemical D & C yellow no. 11 
1         
 50 1016 900 0.886 18.00 26.0 79.961 
1.5       
 50 1019 844 0.828 16.88 33.0 68.266 
2.7       
 25 504 522 1.036 20.88 33.0 110.411 
5         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1014 629 0.620 12.58 26.0 26.021
Mitomycin-C 
 0.01      
 5 104 191 1.837 38.20 26.0 273.103
Trend: 11.493        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/09/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 457 0.447 9.14 26.0 0.000
Test Chemical D & C yellow no. 11 
2.7       
 50 1012 532 0.526 10.64 26.0 17.562 
8         
 50 1025 631 0.616 12.62 26.0 37.670 
27         
 50 1028 1055 1.026 21.10 34.5 129.506 
80         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1010 738 0.731 14.76 26.0 63.407
Cyclophosphamide 
2         
 5 103 245 2.379 49.00 26.0 431.941
Trend: 16.322        
Probability: 0.000