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Study Information
Study Attribute Value
CEBS Accession Number: 002-01942-0002-0000-0
Chemical Name: D & C yellow no. 11
CASRN: 8003-22-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 296632_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 08/08/1985    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 4 0.020 1.5 0 0.000 0.0 4 0.020 1.5 0 0.000 0.0
Test Chemical: D & C yellow no. 11 
10         
 25 16 0.640 40.0 11 0.440 32.0 4 0.160 12.0 1 0.040 4.0 
12.5       
 25 18 0.720 40.0 9 0.360 24.0 9 0.360 20.0 0 0.000 0.0 
15         
 50 28 0.560 40.0 13 0.260 20.0 15 0.300 22.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 200 24 0.120 9.5 14 0.070 6.0 10 0.050 4.5 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 9 0.360 24.0 4 0.160 16.0 5 0.200 16.0 0 0.000 0.0
Trend: 8.203 5.879 5.630  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/21/1985    Harvest Time: 21.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0
Test Chemical: D & C yellow no. 11 
60         
 25 92 3.680 88.0 45 1.800 84.0 37 1.480 68.0 10 0.400 4.0 
69.7       
 25 109 4.360 80.0 31 1.240 52.0 38 1.520 52.0 40 1.600 16.0 
80         
 25 86 3.440 76.0 23 0.920 52.0 23 0.920 44.0 40 1.600 16.0
Positive Control: Cyclophosphamide 
6.25      
 200 32 0.160 12.0 10 0.050 5.0 22 0.110 9.5 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 44 1.760 68.0 18 0.720 44.0 26 1.040 68.0 0 0.000 0.0
Trend: 12.464 9.626 9.209  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 05/23/1985    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: D & C yellow no. 11 
5         
 200 37 0.185 16.0 20 0.100 9.0 17 0.085 8.5 0 0.000 0.0 
7.5       
 50 12 0.240 20.0 6 0.120 10.0 6 0.120 10.0 0 0.000 0.0 
10         
 100 18 0.180 13.0 12 0.120 10.0 6 0.060 6.0 0 0.000 0.0 
15         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 200 32 0.160 9.5 15 0.075 5.5 17 0.085 7.5 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 10 0.400 28.0 6 0.240 24.0 4 0.160 12.0 0 0.000 0.0
Trend: 3.841 3.464 2.210  
Probability: 0.000 0.000 0.014