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Study Information
Study Attribute Value
CEBS Accession Number: 002-01945-0001-0000-2
Chemical Name: D-Carvone
CASRN: 2244-16-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 983543_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/22/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 333 0.317 6.66 25.8 0.000
Test Chemical D-Carvone 
 0.502     
 50 1050 423 0.403 8.46 25.8 27.027 
1.67      
 50 1049 542 0.517 10.84 25.8 62.918 
5         
 50 1046 536 0.512 10.72 25.8 61.576 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 610 0.581 12.20 25.8 83.183
Mitomycin-C 
 0.01      
 5 105 196 1.867 39.20 25.8 488.589
Trend: 7.712        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/11/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 521 279 0.536 11.16 25.8 0.000
Negative (Not Specified) 
0         
 25 523 302 0.577 12.08 25.8 7.830
Test Chemical D-Carvone 
5         
 25 519 326 0.628 13.04 25.8 17.296 
15         
 25 517 394 0.762 15.76 25.8 42.311 
20         
 25 514 389 0.757 15.56 25.8 41.325 
25         
 0 0 0 0.000 0.00 25.8 N/A
Positive Control Mitomycin-C 
 0.001     
 25 522 368 0.705 14.72 25.8 31.647
Mitomycin-C 
 0.01      
 5 105 259 2.467 51.80 25.8 360.621
Trend: 5.178        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/22/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 350 0.333 7.00 25.8 0.000
Test Chemical D-Carvone 
50.2       
 50 1049 371 0.354 7.42 25.8 6.101 
167.3       
 50 1048 490 0.468 9.80 25.8 40.267 
501.8       
 50 1049 427 0.407 8.54 25.8 22.116 
1700         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1048 616 0.588 12.32 25.8 76.336
Cyclophosphamide 
2         
 5 105 181 1.724 36.20 25.8 417.143
Trend: 3.950        
Probability: 0.000