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Study Information
Study Attribute Value
CEBS Accession Number: 002-01948-0014-0000-9
Chemical Name: D-Mannitol
CASRN: 69-65-8
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 741772_CA
Study Result: Negative (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/27/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0260
Test Group Dose
(g/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 5.75 ± 1.94 0.0058
Test Chemical D-Mannitol 
2.5       
 8 1.50 ± 0.63 0.7829
  
5         
 8 1.75 ± 0.70 0.6932
  
10         
 8 4.00 ± 1.20 0.0775
Vehicle Control No Stressor 
 0         
 8 2.25 ± 0.45 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/21/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0836
Test Group Dose
(g/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 9.00 ± 1.85 0.0000
Test Chemical D-Mannitol 
5         
 8 2.25 ± 0.80 0.3068
  
10         
 8 3.25 ± 0.37 0.0871
Vehicle Control No Stressor 
 0         
 8 1.75 ± 0.59 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed