| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01948-0014-0000-9 |
| Chemical Name: | D-Mannitol |
| CASRN: | 69-65-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 741772_CA |
| Study Result: | Negative (Nonstandard Protocol) |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|
| CA | 01/27/87 | 17 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 17 hour | 0.0260 |
| Test Group | Dose (g/kg) | n | Percent Cells w/ Aberrations (Mean ± SEM) | Pairwise P | |
|---|---|---|---|---|---|
| Positive Control | Mitomycin-C | 1 | 8 | 5.75 ± 1.94 | 0.0058 |
| Test Chemical | D-Mannitol | 2.5 | 8 | 1.50 ± 0.63 | 0.7829 |
5 | 8 | 1.75 ± 0.70 | 0.6932 | ||
10 | 8 | 4.00 ± 1.20 | 0.0775 | ||
| Vehicle Control | No Stressor | 0 | 8 | 2.25 ± 0.45 | 0.0000 |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|
| CA | 04/21/87 | 17 | Mouse | Male | Bone Marrow | Intraperitoneal Injection x 1/study, 17 hour | 0.0836 |
| Test Group | Dose (g/kg) | n | Percent Cells w/ Aberrations (Mean ± SEM) | Pairwise P | |
|---|---|---|---|---|---|
| Positive Control | Mitomycin-C | 1 | 8 | 9.00 ± 1.85 | 0.0000 |
| Test Chemical | D-Mannitol | 5 | 8 | 2.25 ± 0.80 | 0.3068 |
10 | 8 | 3.25 ± 0.37 | 0.0871 | ||
| Vehicle Control | No Stressor | 0 | 8 | 1.75 ± 0.59 | 0.0000 |
Footnotes: IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed
INHAL: Inhalation
n: Number of animals analyzed