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Study Information
Study Attribute Value
CEBS Accession Number: 002-01950-0001-0000-8
Chemical Name: D-alpha-Tocopheryl succinate
CASRN: 4345-03-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 185103_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 12/13/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 468 0.456 9.36 25.3 0.000
Test Chemical D-alpha-Tocopheryl succinate 
5         
 50 1003 484 0.483 9.68 25.3 5.790 
7         
 50 1036 482 0.465 9.64 25.3 1.997 
10         
 50 1005 479 0.477 9.58 25.3 4.489 
50         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1021 714 0.699 14.28 25.3 53.311
Mitomycin-C 
 0.01      
 5 104 244 2.346 48.80 25.3 414.349
Trend: 0.587        
Probability: 0.279        

Trial #: 2    Activation: No Activation    Date: 01/11/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1027 469 0.457 9.38 25.8 0.000
Test Chemical D-alpha-Tocopheryl succinate 
15.1       
 50 1029 410 0.398 8.20 25.8 -12.750 
19.95      
 50 1029 487 0.473 9.74 32.8 3.636 
25.2       
 50 1035 504 0.487 10.08 32.8 6.632 
30.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1037 662 0.638 13.24 25.8 39.790
Mitomycin-C 
 0.01      
 5 102 264 2.588 52.80 25.8 466.763
Trend: 1.848        
Probability: 0.032        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/06/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 494 0.482 9.88 25.3 0.000
Test Chemical D-alpha-Tocopheryl succinate 
30         
 50 1017 531 0.522 10.62 25.3 8.335 
100         
 50 1024 561 0.548 11.22 25.3 13.674 
300         
 50 1012 655 0.647 13.10 34.1 34.294 
1000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1012 734 0.725 14.68 25.3 50.492
Cyclophosphamide 
2         
 5 101 204 2.020 40.80 25.3 319.088
Trend: 4.986        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/13/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1012 538 0.532 10.76 25.3 0.000
Test Chemical D-alpha-Tocopheryl succinate 
202         
 50 1024 618 0.604 12.36 25.3 13.524 
298.2       
 50 1021 610 0.597 12.20 25.3 12.383 
396         
 50 1017 730 0.718 14.60 25.3 35.021 
497         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1018 865 0.850 17.30 25.3 59.833
Cyclophosphamide 
2         
 5 104 226 2.173 45.20 25.3 308.765
Trend: 4.896        
Probability: 0.000