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Study Information
Study Attribute Value
CEBS Accession Number: 002-01955-0001-0000-3
Chemical Name: DL-amphetamine sulfate
CASRN: 60-13-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 381641_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Negative 
Induced Rat Liver S9  3_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/05/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 381 0.363 7.62 26.0 0.000
Test Chemical DL-amphetamine sulfate 
5         
 50 1046 388 0.371 7.76 26.0 2.227 
16         
 50 1045 402 0.385 8.04 26.0 6.017 
50         
 50 1048 351 0.335 7.02 26.0 -7.698 
160         
 50 1048 359 0.343 7.18 26.0 -5.594
Positive Control Mitomycin-C 
 0.0E-4    
 50 1047 500 0.478 10.00 26.0 31.610
Mitomycin-C 
 0.005     
 10 210 338 1.610 33.80 26.0 343.570
Trend: -1.303        
Probability: 0.904        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/05/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 372 0.355 7.44 26.0 0.000
Test Chemical DL-amphetamine sulfate 
50         
 50 1047 459 0.438 9.18 26.0 23.623 
160         
 50 1047 449 0.429 8.98 26.0 20.929 
500         
 50 1050 447 0.426 8.94 26.0 20.047 
1600         
 50 1050 399 0.380 7.98 26.0 7.156
Positive Control Cyclophosphamide 
 0.1       
 50 1048 475 0.453 9.50 26.0 27.810
Cyclophosphamide 
 0.6       
 10 210 198 0.943 19.80 26.0 165.876
Trend: 0.614        
Probability: 0.270        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/02/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1047 396 0.378 7.92 26.0 0.000
Test Chemical DL-amphetamine sulfate 
50         
 50 1041 412 0.396 8.24 26.0 4.640 
160         
 50 1050 397 0.378 7.94 26.0 -0.034 
500         
 50 1049 438 0.418 8.76 26.0 10.395 
1600         
 50 1043 400 0.384 8.00 26.0 1.397
Positive Control Cyclophosphamide 
 0.1       
 50 1049 547 0.521 10.94 26.0 37.868
Cyclophosphamide 
 0.6       
 10 208 238 1.144 23.80 26.0 202.528
Trend: 0.528        
Probability: 0.299        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 12/13/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 375 0.359 7.50 26.0 0.000
Test Chemical DL-amphetamine sulfate 
50         
 50 1045 388 0.371 7.76 26.0 3.368 
160         
 50 1050 391 0.372 7.82 26.0 3.671 
500         
 50 1041 399 0.383 7.98 26.0 6.707 
1600         
 50 1049 408 0.389 8.16 26.0 8.281
Positive Control Cyclophosphamide 
 0.15      
 50 1044 499 0.478 9.98 26.0 33.067
Cyclophosphamide 
 0.6       
 10 207 182 0.879 18.20 26.0 144.777
Trend: 1.193        
Probability: 0.116