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Study Information
Study Attribute Value
CEBS Accession Number: 002-01957-0002-0000-6
Chemical Name: DL-menthol
CASRN: 89-78-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 423321_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/11/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 12 0.060 4.0 1 0.005 1.0 11 0.055 4.0 0 0.000 0.0
Test Chemical: DL-menthol 
100.5       
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
150         
 200 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
200         
 200 8 0.040 4.0 0 0.000 0.0 8 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 200 26 0.130 10.0 16 0.080 6.0 10 0.050 5.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 10 0.400 32.0 3 0.120 12.0 6 0.240 20.0 1 0.040 4.0
Trend: -0.060 -0.212 -0.561  
Probability: 0.524 0.584 0.713  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/11/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: DL-menthol 
50         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
123.7       
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
250         
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 14 0.140 14.0 7 0.070 7.0 7 0.070 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 12 0.480 40.0 5 0.200 20.0 7 0.280 24.0 0 0.000 0.0
Trend: -0.275 -0.430 -0.056  
Probability: 0.608 0.666 0.522