Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01957-0002-0000-6
Chemical Name: DL-menthol
CASRN: 89-78-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 423321_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/11/1985    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 12 0.060 4.0 1 0.005 1.0 11 0.055 4.0 0 0.000 0.0
Test Chemical: DL-menthol 
100.5       
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
150         
 200 4 0.020 2.0 4 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
200         
 200 8 0.040 4.0 0 0.000 0.0 8 0.040 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 200 26 0.130 10.0 16 0.080 6.0 10 0.050 5.0 0 0.000 0.0
Mitomycin-C 
 0.5       
 25 10 0.400 32.0 3 0.120 12.0 6 0.240 20.0 1 0.040 4.0
Trend: -0.060 -0.212 -0.561  
Probability: 0.524 0.584 0.713  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/11/1985    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Test Chemical: DL-menthol 
50         
 200 4 0.020 2.0 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 
123.7       
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
250         
 200 8 0.040 4.0 2 0.010 1.0 6 0.030 3.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 14 0.140 14.0 7 0.070 7.0 7 0.070 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 12 0.480 40.0 5 0.200 20.0 7 0.280 24.0 0 0.000 0.0
Trend: -0.275 -0.430 -0.056  
Probability: 0.608 0.666 0.522