U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01960-0001-0000-9
Chemical Name: Daminozide
CASRN: 1596-84-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 113918_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/31/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 447 0.427 8.94 26.0 0.000
Test Chemical Daminozide 
70.4       
 50 1048 397 0.379 7.94 26.0 -11.186 
220         
 50 1048 380 0.363 7.60 26.0 -14.989 
704         
 50 1046 394 0.377 7.88 26.0 -11.688
Positive Control Mitomycin-C 
 0.005     
 25 523 639 1.222 25.56 26.0 186.453
Trend: -1.928        
Probability: 0.973        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/31/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 375 0.357 7.50 26.0 0.000
Test Chemical Daminozide 
220         
 50 1047 384 0.367 7.68 26.0 2.693 
704         
 50 1048 340 0.324 6.80 26.0 -9.160 
2200         
 25 521 170 0.326 6.80 26.0 -8.637
Positive Control Cyclophosphamide 
1         
 50 1045 790 0.756 15.80 26.0 111.675
Trend: -1.503        
Probability: 0.934