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Study Information
Study Attribute Value
CEBS Accession Number: 002-01960-0002-0000-0
Chemical Name: Daminozide
CASRN: 1596-84-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 113918_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/31/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Daminozide 
220         
 100 5 0.050 4.0 0 0.000 0.0 5 0.050 4.0 0 0.000 0.0 
704         
 100 6 0.060 5.0 1 0.010 1.0 5 0.050 4.0 0 0.000 0.0 
2200         
 100 8 0.080 7.0 0 0.000 0.0 8 0.080 7.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 34 0.680 42.0 7 0.140 12.0 27 0.540 36.0 0 0.000 0.0
Trend: 1.366 0.454 1.292  
Probability: 0.086 0.325 0.098  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/31/1983    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0
Test Chemical: Daminozide 
220         
 100 10 0.100 9.0 2 0.020 2.0 8 0.080 8.0 0 0.000 0.0 
704         
 100 8 0.080 8.0 1 0.010 1.0 7 0.070 7.0 0 0.000 0.0 
2200         
 100 9 0.090 9.0 3 0.030 3.0 6 0.060 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 16 0.320 28.0 4 0.080 8.0 12 0.240 22.0 0 0.000 0.0
Trend: 0.919 0.849 0.463  
Probability: 0.179 0.198 0.322