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Study Information
Study Attribute Value
CEBS Accession Number: 002-01964-0001-0000-3
Chemical Name: Decabromodiphenyl oxide
CASRN: 1163-19-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 856353_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/26/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 463 0.440 9.26 26.0 0.000
Negative (Not Specified) 
0         
 50 1046 476 0.455 9.52 26.0 3.397
Test Chemical Decabromodiphenyl oxide 
 0.05      
 50 1049 507 0.483 10.14 26.0 9.816 
 0.16      
 50 1047 459 0.438 9.18 26.0 -0.391 
 0.5       
 50 1050 472 0.450 9.44 26.0 2.138 
16         
 50 1050 489 0.466 9.78 26.0 5.817 
50         
 50 1051 454 0.432 9.08 26.0 -1.851 
160         
 50 1040 478 0.460 9.56 26.0 4.431 
500         
 25 518 197 0.380 7.88 26.0 -13.589
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 853 0.813 17.06 26.0 84.760
Mitomycin-C 
 0.01      
 10 209 619 2.962 61.90 26.0 572.944
Trend: -1.055        
Probability: 0.854        

Trial #: 2    Activation: No Activation    Date: 07/31/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 425 0.408 8.50 26.5 0.000
Test Chemical Decabromodiphenyl oxide 
50         
 50 1040 405 0.389 8.10 26.5 -4.614 
100         
 50 1043 397 0.381 7.94 26.5 -6.767 
250         
 50 1046 406 0.388 8.12 26.5 -4.927 
500         
 50 1044 380 0.364 7.60 26.5 -10.845
Positive Control Mitomycin-C 
 0.0E-4    
 50 1044 557 0.534 11.14 26.5 30.682
Mitomycin-C 
 0.01      
 10 210 490 2.333 49.00 26.5 471.529
Trend: -1.448        
Probability: 0.926        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/26/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1042 435 0.417 8.70 26.0 7.777
Dimethyl Sulfoxide 
0         
 50 1043 404 0.387 8.08 26.0 0.000
Test Chemical Decabromodiphenyl oxide 
 0.5       
 50 1048 412 0.393 8.24 26.0 1.494 
16         
 50 1035 396 0.383 7.92 26.0 -1.223 
160         
 50 1042 400 0.384 8.00 26.0 -0.895 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1040 527 0.507 10.54 26.0 30.822
Cyclophosphamide 
2         
 10 207 220 1.063 22.00 26.0 174.382
Trend: -0.269        
Probability: 0.606        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/31/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 467 0.448 9.34 26.0 0.000
Test Chemical Decabromodiphenyl oxide 
50         
 50 1047 432 0.413 8.64 26.0 -7.936 
100         
 50 1048 463 0.442 9.26 26.0 -1.424 
250         
 50 1048 419 0.400 8.38 26.0 -10.792 
500         
 50 1046 441 0.422 8.82 26.0 -5.929
Positive Control Cyclophosphamide 
 0.3       
 50 1048 643 0.614 12.86 26.0 36.899
Cyclophosphamide 
2         
 10 210 356 1.695 35.60 26.0 278.252
Trend: -1.086        
Probability: 0.861