COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01964-0002-0000-4
Chemical Name: Decabromodiphenyl oxide
CASRN: 1163-19-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 856353_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 08/02/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Decabromodiphenyl oxide
50         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
100         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
250         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
500         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.15      
100 25 0.250 16.0 15 0.150 11.0 10 0.100 9.0 0 0.000 0.0
Mitomycin-C
 0.25      
100 27 0.270 22.0 22 0.220 20.0 5 0.050 5.0 0 0.000 0.0
Trend: -0.448 0.000 -0.448  
Probability: 0.673 0.000 0.673  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/02/1984    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Decabromodiphenyl oxide
50         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
100         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
250         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
500         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide
15         
100 33 0.330 28.0 21 0.210 18.0 12 0.120 10.0 0 0.000 0.0
Cyclophosphamide
30         
50 27 0.540 40.0 16 0.320 28.0 11 0.220 16.0 0 0.000 0.0
Trend: -0.068 -0.068 -0.039  
Probability: 0.527 0.527 0.516  


Trial #:2   Activation: No Activation    Date: 06/29/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Decabromodiphenyl oxide
16         
100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
50         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
160         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
500         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 25 0.250 24.0 15 0.150 15.0 10 0.100 10.0 0 0.000 0.0
Mitomycin-C
1         
50 35 0.700 44.0 16 0.320 30.0 9 0.180 18.0 10 0.200 1.0
Trend: 0.640 -0.707 1.069  
Probability: 0.261 0.760 0.143  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 06/28/1984    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: Decabromodiphenyl oxide
5         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
16         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
50         
100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
500         
100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0
Positive Control: Cyclophosphamide
15         
100 10 0.100 9.0 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0
Cyclophosphamide
50         
50 27 0.540 38.0 12 0.240 22.0 14 0.280 26.0 1 0.020 1.0
Trend: 0.994 0.000 1.073  
Probability: 0.160 0.000 0.142