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Study Information
Study Attribute Value
CEBS Accession Number: 002-01964-0009-0000-1
Chemical Name: Decabromodiphenyl oxide
CASRN: 1163-19-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 490548
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 117 111 254 72 83
    117 105 255 73
    89 95 266 99
    106 89 283 89
Test Chemical Decabromodiphenyl oxide 
 0.625     
 137r 97 238 58
    103 91 204 66
  
1.25      
 127r 116 202 53
    93 111 196 70
  
2.5       
 103 98 205 66 62
    99 98 173 59
  
5         
 84 83 171 68 66
    98 106 186 63
  
10         
 108 92 238 73 67
    101 80 186 62
Positive Control Methyl Methane Sulfonate 
15         
 29 15 328 375 380*
    36 16 413 386

Nonactivation Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 100 104 178 59 44
    115 93 140 41
    105 107 103 33
    98 96 134 45
Test Chemical Decabromodiphenyl oxide 
7         
 89 87 77 29 41
    90 88 143 53
  
8         
 81 85 97 40 46
    117 125 180 51
  
9         
 90 86 94 35 39
    99 93 130 44
  
10         
 104 99 152 49 44
    97 91 115 40
Positive Control Methyl Methane Sulfonate 
15         
 70 36 762 365 401*
    57 32 750 436

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 80 86 93 39 39
    84 95 118 47
    89 101 106 40
    87 118 83 32
Test Chemical Decabromodiphenyl oxide 
6         
 97 95 87 30 43
    68 94 114 56
  
7         
 86 100 95 37 40
    82 85 106 43
  
8         
 93 97 139 50 47
    95# 84 129 45
  
9         
 112 95 109 33 37
    109 121 137 42
  
10         
 67 103 88 44 45
    74 89 103 47
Positive Control 3-Methylcholanthrene 
2.5       
 41 17 369 299 360*
    31 13 394 421

Induced S9 Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 68 81 87 43 44
    66 86 90 45
    77 120 90 39
    78 112 117 50
Test Chemical Decabromodiphenyl oxide 
7         
 53 84 91 57 51
    57 74 75 44
  
8         
 124r 158 97 26
    64 84 58 30
  
9         
 55 70 51 31 39
    60 76 85 48
  
10         
 52 72 94 61 53
    83# 104 114 46
Positive Control 3-Methylcholanthrene 
2.5       
 36 31 474 437 391*
    53 35 544 344

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination