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Study Information
Study Attribute Value
CEBS Accession Number: 002-01969-0002-0000-9
Chemical Name: Di(2-ethylhexyl) phthalate
CASRN: 117-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 426348_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/25/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1044 500 0.479 10.00 26.0 0.000
Negative (Not Specified) 
0         
 50 1043 481 0.461 9.62 26.0 -3.708
Test Chemical Di(2-ethylhexyl) phthalate 
 0.98      
 50 1046 395 0.378 7.90 26.0 -21.151 
3.27      
 50 1041 595 0.572 11.90 33.8 19.343 
9.82      
 50 1045 585 0.560 11.70 33.8 16.888 
32.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1043 846 0.811 16.92 26.0 69.362
Mitomycin-C 
 0.01      
 5 105 291 2.771 58.20 26.0 478.674
Trend: 4.510        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/06/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 100 2067 1069 0.517 10.69 26.0 8.585
Ethanol 
0         
 100 2045 974 0.476 9.74 26.0 0.000
Test Chemical Di(2-ethylhexyl) phthalate 
10         
 50 1036 586 0.566 11.72 33.8 18.761 
15         
 50 1033 582 0.563 11.64 33.8 18.292 
20         
 50 1026 614 0.598 12.28 33.8 25.648 
25.1       
 0 0 0 0.000 0.00 33.8 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1026 841 0.820 16.82 26.0 72.101
Mitomycin-C 
 0.01      
 5 104 233 2.240 46.60 26.0 370.389
Trend: 4.486        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/25/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1040 676 0.650 13.52 26.0 0.000
Negative (Not Specified) 
0         
 50 1040 565 0.543 11.30 26.0 -16.420
Test Chemical Di(2-ethylhexyl) phthalate 
9.82      
 50 1038 624 0.601 12.48 26.0 -7.514 
982         
 50 1043 679 0.651 13.58 26.0 0.155 
3270         
 50 1045 693 0.663 13.86 26.0 2.024 
9820         
 50 1039 525 0.505 10.50 26.0 -22.263
Positive Control Cyclophosphamide 
 0.4       
 50 1033 809 0.783 16.18 26.0 20.486
Cyclophosphamide 
2         
 5 104 227 2.183 45.40 26.0 235.799
Trend: -1.965        
Probability: 0.975