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Study Information
Study Attribute Value
CEBS Accession Number: 002-01969-0003-0000-0
Chemical Name: Di(2-ethylhexyl) phthalate
CASRN: 117-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 515010_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/26/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 559 0.535 11.18 26.0 7.611
Ethanol 
0         
 50 1029 512 0.498 10.24 26.0 0.000
Test Chemical Di(2-ethylhexyl) phthalate 
 0.99      
 50 1034 527 0.510 10.54 26.0 2.432 
3.31      
 50 1030 629 0.611 12.58 35.3 22.732 
9.94      
 50 1038 616 0.593 12.32 35.3 19.269 
33.1       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1045 921 0.881 18.42 26.0 77.129
Mitomycin-C 
 0.01      
 5 104 283 2.721 56.60 26.0 446.888
Trend: 3.787        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 06/06/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 100 2067 1069 0.517 10.69 26.0 8.585
Ethanol 
0         
 100 2045 974 0.476 9.74 26.0 0.000
Test Chemical Di(2-ethylhexyl) phthalate 
10.1       
 50 1020 567 0.556 11.34 33.8 16.712 
15.2       
 50 1024 586 0.572 11.72 33.8 20.152 
20.3       
 50 1020 609 0.597 12.18 33.8 25.358 
25.4       
 0 0 0 0.000 0.00 33.8 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1026 841 0.820 16.82 26.0 72.101
Mitomycin-C 
 0.01      
 5 104 233 2.240 46.60 26.0 370.389
Trend: 4.624        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/26/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1044 707 0.677 14.14 26.0 0.000
Negative (Not Specified) 
0         
 50 1041 564 0.542 11.28 26.0 -19.996
Test Chemical Di(2-ethylhexyl) phthalate 
9.9       
 50 1043 572 0.548 11.44 26.0 -19.017 
3310         
 50 1047 753 0.719 15.06 26.0 6.201 
9940         
 50 1041 689 0.662 13.78 26.0 -2.265
Positive Control Cyclophosphamide 
 0.4       
 50 1047 854 0.816 17.08 26.0 20.446
Cyclophosphamide 
2         
 5 105 269 2.562 53.80 26.0 278.307
Trend: 1.769        
Probability: 0.038