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Study Information
Study Attribute Value
CEBS Accession Number: 002-01969-0005-0000-2
Chemical Name: Di(2-ethylhexyl) phthalate
CASRN: 117-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 594940_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/12/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 464 0.443 9.28 26.0 0.000
Test Chemical Di(2-ethylhexyl) phthalate 
 0.5       
 50 1049 468 0.446 9.36 26.0 0.670 
1.5       
 50 1048 480 0.458 9.60 26.0 3.350 
5         
 50 1048 488 0.466 9.76 26.0 5.072 
15         
 17 356 185 0.520 10.88 26.0 17.260
Positive Control Triethylenemelamine 
 0.015     
 50 1049 1904 1.815 38.08 26.0 309.562
Trend: 1.658        
Probability: 0.049        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/12/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 408 0.389 8.16 26.0 0.000
Test Chemical Di(2-ethylhexyl) phthalate 
150         
 50 1049 431 0.411 8.62 28.0 5.637 
500         
 50 1048 464 0.443 9.28 28.0 13.834 
1500         
 50 1050 466 0.444 9.32 28.0 14.107
Positive Control Cyclophosphamide 
1         
 50 1049 1349 1.286 26.98 26.0 230.637
Trend: 2.203        
Probability: 0.014