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Study Information
Study Attribute Value
CEBS Accession Number: 002-01969-0006-0000-3
Chemical Name: Di(2-ethylhexyl) phthalate
CASRN: 117-81-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 594940_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/12/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Di(2-ethylhexyl) phthalate 
150         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
500         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0 
1500         
 100 4 0.040 4.0 0 0.000 0.0 4 0.040 4.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.15      
 100 39 0.390 28.0 15 0.150 15.0 24 0.240 18.0 0 0.000 0.0
Trend: 1.347 -0.456 1.590  
Probability: 0.089 0.676 0.056  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/12/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Di(2-ethylhexyl) phthalate 
150         
 100 7 0.070 4.0 3 0.030 2.0 4 0.040 3.0 0 0.000 0.0 
500         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0 
1500         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 52 0.520 35.0 25 0.250 22.0 27 0.270 18.0 0 0.000 0.0
Trend: 1.580 0.997 1.032  
Probability: 0.057 0.159 0.151