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Study Information
Study Attribute Value
CEBS Accession Number: 002-01970-0001-0000-0
Chemical Name: Di(2-ethylhexyl)adipate
CASRN: 103-23-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 783757_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 03/12/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 464 0.443 9.28 26.0 0.000
Test Chemical Di(2-ethylhexyl)adipate 
40         
 50 1047 478 0.457 9.56 28.0 3.017 
130         
 50 1046 492 0.470 9.84 28.0 6.136 
400         
 50 1047 523 0.500 10.46 28.0 12.716
Positive Control Triethylenemelamine 
 0.015     
 50 1049 1904 1.815 38.08 26.0 309.562
Trend: 1.932        
Probability: 0.027        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/12/1981    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 408 0.389 8.16 26.0 0.000
Test Chemical Di(2-ethylhexyl)adipate 
40         
 50 1048 419 0.400 8.38 28.0 2.794 
130         
 50 1050 458 0.436 9.16 28.0 12.148 
400         
 50 1048 483 0.461 9.66 28.0 18.495
Positive Control Cyclophosphamide 
1         
 50 1049 1349 1.286 26.98 26.0 230.637
Trend: 2.814        
Probability: 0.002