Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01970-0002-0000-1 |
Chemical Name: | Di(2-ethylhexyl)adipate |
CASRN: | 103-23-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 783757_CA |
Study Result: | Weakly Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Weakly Positive |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Di(2-ethylhexyl)adipate | 40 | 100 | 3 | 0.030 | 3.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
130 | 100 | 5 | 0.050 | 4.0 | 2 | 0.020 | 2.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | ||
400 | 100 | 11 | 0.110 | 7.0 | 2 | 0.020 | 2.0 | 9 | 0.090 | 5.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Triethylenemelamine | 0.15 | 100 | 39 | 0.390 | 28.0 | 15 | 0.150 | 15.0 | 24 | 0.240 | 18.0 | 0 | 0.000 | 0.0 |
Trend: | 2.232 | 1.413 | 1.711 | ||||||||||||
Probability: | 0.013 | 0.079 | 0.044 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Dimethyl Sulfoxide | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Di(2-ethylhexyl)adipate | 40 | 100 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 |
130 | 100 | 7 | 0.070 | 5.0 | 0 | 0.000 | 0.0 | 7 | 0.070 | 5.0 | 0 | 0.000 | 0.0 | ||
400 | 100 | 6 | 0.060 | 6.0 | 1 | 0.010 | 1.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 15 | 100 | 52 | 0.520 | 35.0 | 25 | 0.250 | 22.0 | 27 | 0.270 | 18.0 | 0 | 0.000 | 0.0 |
Trend: | 1.294 | 1.335 | 0.999 | ||||||||||||
Probability: | 0.098 | 0.091 | 0.159 |