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Study Information
Study Attribute Value
CEBS Accession Number: 002-01976-0001-0000-6
Chemical Name: Di(p-ethylphenyl)dichloroethane
CASRN: 72-56-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 622798_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Questionable 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/27/1987    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 333 0.317 6.66 25.8 0.000
Test Chemical Di(p-ethylphenyl)dichloroethane 
 0.5       
 50 1048 430 0.410 8.60 25.8 29.376 
1.7       
 50 1049 360 0.343 7.20 25.8 8.211 
5         
 50 1046 335 0.320 6.70 25.8 0.985 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 518 0.493 10.36 25.8 55.556
Mitomycin-C 
 0.01      
 5 105 191 1.819 38.20 25.8 473.574
Trend: -0.692        
Probability: 0.756        

Trial #: 2    Activation: No Activation    Date: 09/09/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 525 168 0.320 6.72 25.8 0.000
Test Chemical Di(p-ethylphenyl)dichloroethane 
 0.5       
 50 1037 308 0.297 6.16 25.8 -7.184 
2.5       
 25 525 167 0.318 6.68 25.8 -0.595 
5         
 25 524 192 0.366 7.68 25.8 14.504 
10         
 25 523 228 0.436 9.12 25.8 36.233 
16.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 25 525 287 0.547 11.48 25.8 70.833
Mitomycin-C 
 0.01      
 5 105 205 1.952 41.00 25.8 510.119
Trend: 3.872        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/27/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 504 0.483 10.08 25.8 0.000
Test Chemical Di(p-ethylphenyl)dichloroethane 
5         
 50 1051 440 0.419 8.80 25.8 -13.280 
16.7       
 50 1047 490 0.468 9.80 34.3 -3.056 
50         
 50 1038 502 0.484 10.04 34.3 0.179 
166.7       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1048 743 0.709 14.86 25.8 46.858
Cyclophosphamide 
2         
 5 104 149 1.433 29.80 25.8 196.772
Trend: 0.545        
Probability: 0.293