Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01976-0002-0000-7 |
Chemical Name: | Di(p-ethylphenyl)dichloroethane |
CASRN: | 72-56-0 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 622798_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Di(p-ethylphenyl)dichloroethane | 7.5 | 200 | 5 | 0.025 | 1.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 1.0 | 0 | 0.000 | 0.0 |
11.25 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
15 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
37.5 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.05 | 200 | 23 | 0.115 | 10.5 | 10 | 0.050 | 5.0 | 13 | 0.065 | 5.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.08 | 25 | 20 | 0.800 | 52.0 | 8 | 0.320 | 32.0 | 12 | 0.480 | 28.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.413 | 0.000 | 0.582 | ||||||||||||
Probability: | 0.340 | 0.500 | 0.280 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | |
Test Chemical: | Di(p-ethylphenyl)dichloroethane | 12.5 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
18.75 | 200 | 5 | 0.025 | 2.5 | 1 | 0.005 | 0.5 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
25 | 200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
62.5 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 200 | 21 | 0.105 | 9.5 | 5 | 0.025 | 2.5 | 16 | 0.080 | 7.5 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 37.5 | 25 | 14 | 0.560 | 44.0 | 8 | 0.320 | 28.0 | 6 | 0.240 | 24.0 | 0 | 0.000 | 0.0 | |
Trend: | 1.969 | 1.716 | 1.223 | ||||||||||||
Probability: | 0.024 | 0.043 | 0.111 |