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Study Information
Study Attribute Value
CEBS Accession Number: 002-01984-0001-0000-5
Chemical Name: Diallyl phthalate
CASRN: 131-17-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 154517_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/17/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 437 0.418 8.74 26.5 0.000
Test Chemical Diallyl phthalate 
1.6       
 50 1047 381 0.364 7.62 26.5 -12.981 
5         
 50 1051 401 0.382 8.02 26.5 -8.762 
16         
 50 1048 416 0.397 8.32 26.5 -5.078 
50         
 50 1049 414 0.395 8.28 26.5 -5.624 
160         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 603 0.576 12.06 26.5 37.854
Mitomycin-C 
 0.005     
 10 210 239 1.138 23.90 26.5 172.153
Trend: -0.226        
Probability: 0.590        

Trial #: 2    Activation: No Activation    Date: 05/21/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 369 0.351 7.38 26.5 0.000
Test Chemical Diallyl phthalate 
50         
 50 1050 371 0.353 7.42 26.5 0.542 
75         
 50 1050 384 0.366 7.68 26.5 4.065 
100         
 50 1050 418 0.398 8.36 36.5 13.279 
125         
 50 1048 387 0.369 7.74 36.5 5.078 
160         
 0 0 0 0.000 0.00 36.5 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 511 0.487 10.22 26.5 38.614
Mitomycin-C 
 0.005     
 10 210 239 1.138 23.90 26.5 223.848
Trend: 1.444        
Probability: 0.074        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/17/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 405 0.387 8.10 26.0 0.000
Test Chemical Diallyl phthalate 
5         
 50 1046 389 0.372 7.78 26.0 -3.951 
16         
 50 1047 375 0.358 7.50 26.0 -7.496 
50         
 50 1046 411 0.393 8.22 26.0 1.481 
160         
 50 1049 735 0.701 14.70 26.0 80.962
Positive Control Cyclophosphamide 
 0.3       
 50 1043 900 0.863 18.00 26.0 122.861
Cyclophosphamide 
 0.6       
 10 210 269 1.281 26.90 26.0 230.834
Trend: 9.985        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/21/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 423 0.404 8.46 26.0 0.000
Test Chemical Diallyl phthalate 
5         
 50 1048 427 0.407 8.54 26.0 0.946 
16         
 50 1045 442 0.423 8.84 26.0 4.792 
50         
 50 1045 462 0.442 9.24 26.0 9.533 
160         
 50 1049 546 0.520 10.92 26.0 28.955
Positive Control Cyclophosphamide 
 0.2       
 50 1049 743 0.708 14.86 26.0 75.483
Cyclophosphamide 
 0.6       
 10 210 236 1.124 23.60 26.0 178.428
Trend: 4.148        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 07/09/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 446 0.424 8.92 26.0 0.000
Test Chemical Diallyl phthalate 
100         
 50 1050 498 0.474 9.96 26.0 11.766 
150         
 50 1049 500 0.477 10.00 26.0 12.321 
200         
 50 1049 626 0.597 12.52 26.0 40.626 
250         
 50 1049 831 0.792 16.62 26.0 86.678
Positive Control Cyclophosphamide 
 0.2       
 50 1048 738 0.704 14.76 26.0 65.945
Cyclophosphamide 
 0.6       
 10 211 270 1.280 27.00 26.0 201.543
Trend: 11.284        
Probability: 0.000