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Study Information
Study Attribute Value
CEBS Accession Number: 002-01984-0002-0000-6
Chemical Name: Diallyl phthalate
CASRN: 131-17-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 154517_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Negative 
Induced Rat Liver S9  2_S9  Weakly Positive* 
No Activation  3  Negative 

Trial #:1   Activation: No Activation    Date: 06/19/1985    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0
Test Chemical: Diallyl phthalate 
100         
 200 3 0.015 2.0 1 0.005 1.0 2 0.010 1.0 0 0.000 0.0 
160         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
300         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 200 88 0.440 32.0 40 0.200 17.0 48 0.240 22.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 29 0.580 42.0 10 0.200 18.0 19 0.380 30.0 0 0.000 0.0
Trend: -0.551 -0.595 -0.291  
Probability: 0.709 0.724 0.614  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/19/1985    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 3.0 0 0.000 0.0 5 0.025 3.0 0 0.000 0.0
Test Chemical: Diallyl phthalate 
100         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
160         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
300         
 200 53 0.265 15.0 21 0.105 9.0 32 0.160 10.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 200 121 0.605 41.0 33 0.165 15.0 88 0.440 35.0 0 0.000 0.0
Cyclophosphamide 
10         
 50 31 0.620 480.0 8 0.160 16.0 23 0.460 38.0 0 0.000 0.0
Trend: 5.764 5.973 3.964  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 07/30/1985    Harvest Time: 17 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 2.0 1 0.005 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Diallyl phthalate 
300         
 200 9 0.045 4.0 1 0.005 1.0 8 0.040 3.0 0 0.000 0.0 
400         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
500         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 89 0.445 34.0 42 0.210 20.0 47 0.235 20.0 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 45 0.900 58.0 27 0.540 42.0 18 0.360 28.0 0 0.000 0.0
Trend: -0.425 -1.825 0.446  
Probability: 0.665 0.966 0.328  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/30/1985    Harvest Time: 18 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 2.0 0 0.000 0.0 3 0.015 2.0 0 0.000 0.0
Test Chemical: Diallyl phthalate 
50         
 200 2 0.010 1.0 1 0.005 1.0 1 0.005 1.0 0 0.000 0.0 
100         
 200 1 0.005 1.0 0 0.000 0.0 1 0.005 1.0 0 0.000 0.0 
200         
 200 31 0.155 11.0 18 0.090 8.0 13 0.065 6.0 0 0.000 0.0 
300         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 215 1.075 63.0 113 0.565 42.0 102 0.510 41.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 94 1.880 72.0 45 0.900 54.0 39 0.780 48.0 10 0.200 1.0
Trend: 4.602 4.975 2.505  
Probability: 0.000 0.000 0.006  


Trial #:3   Activation: No Activation    Date: 07/30/1985    Harvest Time: 19 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 2.0 1 0.005 1.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: Diallyl phthalate 
200         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
300         
 200 3 0.015 1.0 0 0.000 0.0 3 0.015 1.0 0 0.000 0.0 
400         
 200 6 0.030 2.0 1 0.005 1.0 5 0.025 2.0 0 0.000 0.0 
500         
 96 7 0.073 5.0 2 0.021 2.0 5 0.052 5.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.063     
 200 93 0.465 32.0 56 0.280 22.0 37 0.185 15.0 0 0.000 0.0
Mitomycin-C 
 0.125     
 50 41 0.820 44.0 24 0.480 30.0 17 0.340 26.0 0 0.000 0.0
Trend: 1.665 0.883 2.561  
Probability: 0.048 0.189 0.005