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Study Information
Study Attribute Value
CEBS Accession Number: 002-01987-0001-0000-8
Chemical Name: Diarylanilide yellow
CASRN: 6358-85-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 659162_SCE
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Questionable 

Trial #: 1    Activation: No Activation    Date: 09/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 502 0.479 10.04 26.0 0.000
Test Chemical Diarylanilide yellow 
16         
 50 1050 514 0.490 10.28 26.0 2.195 
50         
 50 1048 484 0.462 9.68 26.0 -3.586 
160         
 50 1047 540 0.516 10.80 26.0 7.672 
250         
 50 1038 516 0.497 10.32 26.0 3.779
Positive Control Mitomycin-C 
 0.001     
 50 1050 714 0.680 14.28 26.0 41.960
Mitomycin-C 
 0.01      
 10 211 526 2.493 52.60 26.0 420.428
Trend: 0.963        
Probability: 0.168        

Trial #: 2    Activation: No Activation    Date: 11/27/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 488 0.465 9.76 27.0 0.000
Test Chemical Diarylanilide yellow 
25         
 50 1041 477 0.458 9.54 27.0 -1.503 
50         
 50 1044 484 0.464 9.68 31.0 -0.345 
100         
 50 1045 489 0.468 9.78 31.0 0.588 
150         
 50 1037 414 0.399 8.28 31.0 -14.182 
200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1049 642 0.612 12.84 27.0 31.557
Mitomycin-C 
 0.005     
 10 212 321 1.514 32.10 27.0 225.480
Trend: -1.692        
Probability: 0.955        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/30/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 425 0.407 8.50 26.0 0.000
Test Chemical Diarylanilide yellow 
1.6       
 50 1048 449 0.428 8.98 26.0 5.345 
5         
 50 1050 462 0.440 9.24 26.0 8.188 
16         
 50 1045 439 0.420 8.78 26.0 3.294 
50         
 50 1047 445 0.425 8.90 26.0 4.506
Positive Control Cyclophosphamide 
 0.3       
 50 1047 635 0.606 12.70 26.0 49.126
Cyclophosphamide 
 0.6       
 10 209 186 0.890 18.60 26.0 118.824
Trend: 0.442        
Probability: 0.329        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/27/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 409 0.390 8.18 26.0 0.000
Test Chemical Diarylanilide yellow 
100         
 50 1050 416 0.396 8.32 26.0 1.711 
150         
 50 1049 445 0.424 8.90 26.0 8.906 
200         
 50 1043 504 0.483 10.08 26.0 24.054 
250         
 50 1048 489 0.467 9.78 26.0 19.788
Positive Control Cyclophosphamide 
 0.3       
 50 1044 652 0.625 13.04 26.0 60.329
Cyclophosphamide 
 0.6       
 10 210 177 0.843 17.70 26.0 116.381
Trend: 3.810        
Probability: 0.000